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Semaglutide influences the metabolism of dopamine in NAc of alcohol-drinking male and female rats and enhances dopamine driven behaviours in alcohol nave male and female rats To confirm the enhanced dopamine metabolism observed in male mice, ex vivo levels of dopamine and its metabolites were measured in NAc in alcohol-drinking male and female rats treated with semaglutide

The effect of the intervention on hand grip test was significant, evidenced by significant differences in the percent of mean changes between the two intervention arms

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