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At the same time, side effects, limited tools for tracking drug access to the brain, and gaps in understanding long-term neural adaptations all complicate translation to the clinic

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Additionally, it is believed that the PPG neurons are not the only source of GLP-1 in the brain, as gut-derived GLP-1 has been implicated in satiety studies to exert its effects on the brain as well [52]

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PMID: 10642684