Genomic epidemiology methods further suggest a potential link between the increasing clinical incidence of azole-resistant IA and the increasingly widespread presence of azole-resistant genotypes in environmental isolates ( 3 Common antifungal drugs and associated resistance mechanisms Common antifungal drugs include polyenes, azoles, allylamines, morpholines, and echinocandins, all of which function as antimetabolic agents targeting essential fungal structures or biosynthetic pathways (Fisher et al., 2022
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