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The doses of atenolol [35, 39] and metoprolol [61,62,63,64] and pretreatment time/schedules for administration were chosen based on prior literature

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Bisgaard LS, Bosteen MH, Fink LN, Srensen CM, Rosendahl A, Mogensen CK, Rasmussen SE, Rolin B, Nielsen LB, Pedersen TX

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Blood samples were immediately centrifuged, and plasma was transferred to pre-prepared tubes containing acetonitrile and an internal standard of Nle-YI-(6) aminohexanoic amide, 100 g/ml in isotonic saline