The all-in-one approach simplifies the transition into GLP-1 therapy and ensures that basic nutritional gaps are covered from the start
Clin Pharmacol Ther 88:801808 Napolitano A, Miller S, Nicholls AW et al (2014) Novel gut-based pharmacology of metformin in patients with type 2 diabetes mellitus
Around 20% did not respond to semaglutide, comparable to the proportion in the general population
Nutrition Considerations Unique to GLP-1 Users Eat Smaller, More Frequent Meals Large meals can worsen nausea or discomfort due to slowed digestion
Standard titration begins at 0.25 mg weekly for 4 weeks, increasing to 0.5 mg for 4 weeks, then 1 mg for 4 weeks, with further increases to 1.7 mg and finally 2.4 mg at monthly intervals for weight management protocols
From the anesthesiologist point of view, the growing number of patients treated with incretin-based therapies undergoing deep sedation and general anesthesia uncover the possible dark side of these drugs such as revealed by many case reports documenting the association between general anesthesia and gastric aspiration of a large amount of gastric content (including undigested food particles) in patients taking GLP1-RAs during the peri-operative period [10,11,12]
