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In addition, liraglutide could also induce the cell cycle arrest of vascular smooth muscle cells through the AMPK pathway, thereby delaying the formation of AS (130)

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2 Materials and methods 2.1 Animal studies Seipin knockout (SKO) mice with germline disruption of the Bscl2 gene were generated as previously described on a C57BL/6J background ( ad libitum access to water and food consisting of a standard rodent chow diet (CRM (P) 801722, Special Diets Services)

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A psyllium husk supplement , 5 to 10 grams daily, taken with plenty of water, is the first-line intervention

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