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Advanced oral GLP-1 therapies require absolute supply chain protection, direct manufacturer tracking, and climate-controlled storage to guarantee packaging seal integrity and safeguard molecule purity

[1] Other safety considerations include risk of gallbladder disease, pancreatitis, diabetic retinopathy complications (particularly with rapid A1c reduction), and hypersensitivity reactions

Liraglutide mean weight change was -6.4%

The investigators compared people who had used these drugs with clinically similar patients who had not received them, then assessed whether either group was more or less likely to develop substance use disorders

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