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While these benefits are well established, the drugs effects on gastrointestinal motility may predispose susceptible patients to several gastrointestinal complications

Ozempic vs Wegovy Side Effects Understanding Ozempic vs Wegovy side effects is important before starting treatment

Patients escalating to maintenance doses of 1015 mg weekly report constipation more frequently than those staying below 10 mg, suggesting a dose-response relationship

Notable absences: retatrutide is in late-stage trials (TRIUMPH program) but not yet FDA-approved as of May 2026, with the earliest expected approval in late 2026

Furthermore, people with severe gastrointestinal disorders may experience exacerbated symptoms while taking tirzepatide

See Zepbound cost in 2026 and Mounjaro cost in 2026 for the current savings-program landscape