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Results are shown as means

The peptide exhibits high-affinity copper binding (Kd ~10 M), creating a stable complex that delivers copper to cells while protecting against copper-induced oxidative damage

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These biological processes may contribute to healthy aging, cellular repair, and circadian rhythm regulation

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In some embodiments, otic formulations or compositions described herein increase the bioavailability and/or steady state levels of a drug in auris structures (e.g., in inner ear and/or the endolymph and/or the perilymph)