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GSH inhibitors such as buthionine sulfoximine (BSO) were found to improve chemosensitivity in cancer cells

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The antioxidant properties of glutathione are believed to help reduce oxidative stress and inflammation, two key factors implicated in the progression of these neurological conditions

[151] [152] This research subsequently led to the synthesis of the antifolate aminopterin, which was used to treat childhood leukemia by Sidney Farber in 1948