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Introduction Glutathione is a tripeptide found in many tissues at relatively high concentrations, namely 110 mM in cells, similarly to glucose, potassium, and cholesterol, with a critical role in several physiological processes, such as redox balance preservation, reduction of oxidative stress through detoxification from xenobiotic and endogenous compounds, and immune system modulation ( Non-alcoholic fatty liver disease (NAFLD) is the most common liver disease worldwide, characterized by an excessive hepatic fat accumulation in the absence of alcoholic abuse, steatogenic medications or others concomitant liver diseases ( Although the pathogenic role of oxidative stress in NAFLD pathogenesis is well established ( 2
Fasting promotes functional changes in liver mitochondria
Building on the classical perspective, modern evidence reveals that microglia are dynamic participants in disease progression
They assessed the oxido-inflammatory balance in mice stimulated with lipids in vivo
Acknowledgements This work was supported by National Research Foundation grants [2021R1A5A2021614, 2021R1A2C1005513, and 2022M3A9G8095334] funded by the Ministry of Science and ICT of Korea
