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Fe 2+ formed by intestinal absorption or erythrocyte degradation can be oxidized by ceruloplasmin to Fe 3+ , which binds to transferrin (TF) on the cell membrane to form TF-Fe 3+ , which forms a complex through membrane protein TF receptor 1 (TFR1) to endocytose this complex 23

Furthermore, it is highly recommended to take binders on an empty stomach, typically between meals

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Pan Z, Yin H, Wang S, Xiong G, Yin Z (2020) Bcl-xL expression following articular cartilage injury and its effects on the biological function of chondrocytes

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doi: 10.1186/s12935-015-0186-0