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however, most of the studies accept the definition of WR as 10 kg of weight gain after reaching nadir weight

Authorship note: MS and MMH contributed equally to this work

however, this has not been confirmed in humans, and this is not a formal contraindication in UK or EU prescribing information for approved GLP-1 receptor agonists

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Instruct patients to inform their healthcare provider that they are taking XIGDUO XR prior to any surgical or radiological procedure, as temporary discontinuation of XIGDUO XR may be required until renal function has been confirmed to be normal [see WARNINGS AND PRECAUTIONS ]