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Hua C, Boussemart L, and Mateus C, et al Association of vitiligo with tumor response in patients with metastatic melanoma treated with pembrolizumab JAMA Dermatol 152 (1) 4551 PMID: 26501224 20

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Studies in Impaired Glucose Tolerance (IGT) rat models have demonstrated that palmatine treatment markedly improves systemic insulin sensitivity and blood glucose levels, suggesting a positive modulation of insulin signaling pathways 15,16

While management of the underlying cause of the peripheral neuropathy (if applicable) is essential, treatment of the peripheral neuropathy itself includes combination of oral medication, prescription creams, physical therapy, and regenerative medicine

SSRN2023 May 12