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[DOI] [PMC free article] [PubMed] [Google Scholar] 525.Quotti Tubi L, et al

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Formation of thioethers at cysteine-553, such as with the lipid peroxydation biomarker 4-HNE inhibits the formation of the GCLC(S-S)GCLR holo-enzyme and results in a decrease of GSH production

Impaired Detoxification : Lower glutathione levels can hinder the bodys detoxification processes, making it more challenging to eliminate toxins and waste products

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Most patients see significant results within 3-6 months