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These contribute to weight gain when cortisol levels are elevated

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In addition, treatment of rhabdomyosarcoma cells with anti-IGF-IR mAb or IGF-IR/IR kinase inhibitor leads to increased activation of YES/Src family tyrosine kinase (SFK) [173]

Regarding serious renal events, although the combination showed a lower incidence (1.4 vs 2.0 events per 1000 person-years), the confidence interval was wide (HR 0.67