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10.1016/j.taap.2004.09.008 Toxicol Appl Pharmacol

that if they just have more discipline and resolve, they can successfully lose weight

The lack of central carbon and nitrogen catabolism not only leads to energy deficiency but also reduces the supply of the main metabolite anabolic precursors such as pyruvate, acetyl-CoA, glucose-6-phosphate, and erythrose 4-phosphate used for biomass biosynthesis 21