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DHEA has similar effects on the brain, and lack thereof has been associated with cognitive decline, such as Alzheimers and dementia (9)

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Lysine from dietary sources is considered safe

Or, some adults may qualify if they are overweight and have at least one weight-related health condition

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The p53 target gene spermidine/spermine N1-acetyltransferase 1 (SSAT1) can activate the expression of ALOX15, increase ROS production, trigger lipid peroxidation, and induce cell death (56)