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Adaption to erastin insult reprograms cellular cysteine metabolism Erastin inhibits the transmembrane cystineglutamate antiporter system X c , blocks cystine influx, leading to intracellular cysteine shortage and consequently depletion of GSH, causing extensive lipid peroxidation, a featured event in ferroptosis
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Oral supplementation of nicotinamide riboside alters intestinal microbial composition in rats and mice, but not humans
Singh S, Okamura T, Ali-Osman F