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Complications of Cirrhosis Ascites, an increase in free fluid in the abdomen, is the most common complication of cirrhosis Portal hypertension (high blood pressure in the liver) can lead to consequences for kidney, lung, gastrointestinal, and cardiovascular function Gastroesophageal varices, which are abnormal, enlarged veins in the lower part of the esophagus or stomach that can rupture and hemorrhage Liver cancer Hepatic encephalopathy occurs when the dysfunctional liver can no longer metabolize toxins, which build up in the brain, causing cognitive dysfunction, memory problems, mood changes, poor decision making, or delirium