The ewes were fed according to the National Research Council (NRC) (2007) guidelines until day 100 of gestation, after which they were assigned to one of three groups: SPT (G1, n =6), SPT+L-carnitine (G2, n =6), and control (G3, n =6)
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In the HG/TGF--induced HK-2 and STZ-induced diabetic rat models, the expression of the relevant mitochondrial functional proteins PINK1, Parkin, Fundc1, LC3II, Atg5, MFN2, and MFN1 was significantly reduced, and vitamin D receptor (VDR) agonist treatment increased the expression of the relevant proteins, alleviated the dysfunction of mitophagy, inhibited mitochondrial fission, reduced mitochondrial ROS, and increased the integrity of MAMs, leading to the conclusion that VDR agonists can promote the restoration of mitophagy by regulating the MFN2-MAMs-Fundc1 pathway in renal tubular cells, and thus play a nephroprotective role [138]
Indeed, attenuated clinical responses to DPP4i in humans with T2D are associated with the extent of insulin resistance (39)
