cagrilintide and tirzepatide CagriSema vs tirzepatide: which next-generation weight loss treatment wins? Cagrilintide and tirzepatide are NOT

Why it matters: In Eli Lillys Phase 2 trial, the highest dose produced 24.2% mean weight loss at 48 weeks the largest reduction ever reported for an anti-obesity drug at this stage

MattssonCarlgren, N

[38] At the time of suspension, the trial was criticized for other methodological flaws, including being conducted by "fringe" clinicians, and lacking prior Phase I and II studies

Acta Pharmaceutica Sinica B (2023) 13(4):1498521

n = 3 biological replicates

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