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Acknowledgements The authors acknowledge Matthew Wither for generating the untargeted liver metabolomics data

15 , 23 GSH depletion in the brain is a common finding in patients with neurodegenerative conditions eg Alzheimers disease and Parkinsons disease, which can cause neurodegeneration prior to disease onset

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Lower concentrations (25 mg/kg [82], 30 mg/kg [83]) of CBD had no effect on sociability

Intracellular Ca2+ and antioxidant values induced positive effect on fertilisation ratio and oocyte quality of granulosa cells in patients undergoing in vitro fertilisation