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Additionally, topiramate offers the added benefits of weight reduction might via improving insulin resistance in myocytes and adipocytes (Yang et al., 2024), potentially lowering the risk of complications associated with migraines and positively impacting overall patient health

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L-arginine also increases arginase expression, which in turn reduces L-arginine availability (Wang et al., 2006), a mechanism that may partly explain the arginine tolerance hypothesis

[DOI] [PMC free article] [PubMed] [Google Scholar] 206.Amaldoss M.J.N., Yang J.-L., Koshy P., Unnikrishnan A., Sorrell C.C

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