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[DOI] [PubMed] [Google Scholar] 140.Girgis R.R., Baker S., Mao X., Gil R., Javitt D.C., Kantrowitz J.T., Gu M., Spielman D.M., Ojeil N., Xu X., et al

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mice lacking prolactin receptors showed a significant reduction in adipose tissue mass and the number of adipocytes ( in vitro experiments have shown that prolactin receptor (PRLR) gene expression is significantly upregulated during the differentiation of preadipocytes into mature adipocytes, with an approximately 90-fold increase, supporting the functional role of prolactin signaling in adipocyte development and lipid accumulation ( In rodent models, pathological hyperprolactinemia also significantly affects brown adipose tissue (BAT), manifested as the downregulation of thermogenic markers, BAT whitening, and impaired adaptive thermogenesis

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