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R.SamantM.CescatoR.PiccandV.RiekR.et al

ROS have beneficial effects on several physiological processes, including the destruction of pathogens and tissue repair

And indeed, fasting has been shown to have an impressive effect on lifespan

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In the context of the GHK-Cu pathway, which supports tissue regeneration, collagen production, and anti-inflammatory signaling, elevated TNF activity may counteract some of the regenerative benefits by promoting ongoing inflammatory stress within tissues