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In the ATTAIN-2 trial (participants with obesity and type 2 diabetes), GI adverse event rates were somewhat higher than in ATTAIN-1: nausea 20.1-36.4% versus 8.4% with placebo, vomiting 12.8-23.1% versus 3.8%, diarrhea 21.3-27.4% versus 15.0%, and constipation 17.7-22.4% versus 7.8%

While generally safer for cardiovascular patients, GLP-1 therapy requires monitoring for gastrointestinal tolerance and blood sugar fluctuations

Microdosing GLP-1 Is Changing the Way We Approach Metabolic Health Microdosing GLP-1 helps reduce cravings and stabilize appetite without the side effects associated with traditional weight loss protocols