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Deeks JJ, Higgins JPT, Altman DG
To understand why these two medications behave differently, it helps to know that tirzepatide activates two hormone receptors (GIP and GLP-1) while semaglutide targets only the GLP-1 receptor.[1] The added mechanism in tirzepatide is believed to produce stronger appetite suppression and more direct effects on fat tissue
This doesn't mean retatrutide will beat tirzepatide when the Phase 3 results land early trial numbers often shrink
Zarnowski, T., Kleinrok, Z
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