hypertension, type 2 DM, dyslipidemia) A meta-analysis of 22 trials involving over 17,000 patients determined that 50.2% and 17.5% of patients treated with GLP-1RAs (exenatide, semaglutide & liraglutide) experienced a weight loss of 5% and 10% compared to placebo, and that patients without type 2 diabetes achieved a significantly greater weight loss compared to those with diabetes (Vosoughi et al, 2022)
Potential Side Effects of GLP-1s Like any drug, GLP-1s arent perfect
Alcohol Moderate alcohol intake may not have a significant effect on GLP-1 levels, but excessive alcohol consumption can cause blood sugar imbalances and decrease GLP-1 production
So that was the new observation
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For example, a patient with a GLP1R rs6923761 'T' allele may show enhanced GLP-1 receptor sensitivity, potentially supporting a conversation about lower-dose compounded GLP-1 protocols