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Description

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A method for preventing radiation-induced ototoxicity in an individual in need thereof comprising intratympanic administration of a pharmaceutical composition comprising a therapeutic agent selected from a JNK inhibitor, TRPV modulator, an MET channel inhibitor, and an otoprotectant to the individual in need thereof, wherein the pharmaceutical composition is administered prior to onset of radiation therapy, and wherein the composition provides sustained release of the therapeutic agent into the ear for a period of at least 5 days after a single administration

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Product Composition (Per mL) Methionine 20 mg Inositol 50 mg Choline 50 mg Vitamin B12 (Methylcobalamin) Standard dose (varies per compounder, often 1,000 mcg/mL) Total Volume 30 mL multi-dose vial Form Sterile, preservative-free injectable solution Route of Administration Intramuscular only Compounded to USP standards Storage Refrigerate at 28C Mechanism of Action Lipotropic Complex (MIC) MIC stands for Methionine , Inositol , and Choline a trio of nutrients known for their lipotropic (fat-loving) activity

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