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VESALIUS-CV Trial PCSK9 Inhibition in High-Risk Primary Prevention 12,257 high-risk patients (no prior MI/stroke) received evolocumab 140 mg q2w or placebo over 4.5 years

NORMAN SWAN: The company that Professor Sinclair co-founded which had the rights to a formulation of resveratrol was sold to Glaxo Smith Kline for $720 million US

While the oocyte possesses more robust DNA repair mechanisms, its ability to repair sperm DNA damage is finite and decreases with maternal age

Galvankar M, Singh N, Modi D

ablation of the nausea-mediating AP, but not NTS, GLP-1R + neurons eliminates the conditioned taste avoidance response to semaglutide in rodents ( In summary, long-acting GLP-1R agonists primarily reach the circumventricular organs of the hindbrain and food-intake controlling centers of the hypothalamus

In vitro studies using MDCK cells (a model of intestinal epithelial permeability) demonstrated that PLGA nanoparticles significantly enhanced cellular uptake and transport of puerarin across cell monolayers, achieving a permeability coefficient value of 2.83 0.27 10 5 cm/s, which was significantly higher than that observed for free puerarin (0.38 0.07 10 5 cm/s)