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Science Advances
Semaglutide's side effects may include nausea, vomiting, diarrhea, constipation, abdominal pain, decreased appetite, and fatigue
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Results vary among individuals
The stop-start rhythm has also left many wondering whether the drug is temporarily scrambling their hormonal signalling
What Clinical Trials Show In large obesity trials: Average weight loss is ~15% of starting body weight with semaglutide 2.4 mg Average weight loss is ~2022% of starting body weight with tirzepatide 15 mg The majority of weight loss occurs within the first year of treatment Plateaus are common after significant weight reduction Some people lose more, some less but a flattening of the weight-loss curve is expected , especially after meaningful progress has already occurred
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