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Topical diclofenac gel applied directly to the painful area reduces localized inflammation without the systemic downsides of oral NSAIDs

Therefore, CK activity can be used as a surrogate marker for the leakage of these cellular metabolites, which confirms membrane rupture

Subcutaneous means below the skin

The nanoparticles exhibit a drug loading efficiency of 35.1%, a drug loading content of 3.2%, and an average size of 117.3 1.3 nm, with ROS-triggered release enabling targeted delivery to cartilage tissues

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