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Author Contributions L Nel: data curation, formal analysis, validation, investigation, visualization, methodology, project administration, and writingoriginal draft, review, and editing

This disruption results in elevated BBB permeability, and its severity directly correlates with the degree of cerebral edema observed on T2-weighted MR images in both HACE patients and animal models (29, 30)

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EPR spectroscopy Continuous wave EPR spectroscopy was performed at 20 C with a X-band (9.6346 GHz) spectrometer (EMX-Nano, Bruker Biospin, with a cylindric cavity mode TM1110)