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GHK-Cu was found to activate genes related to tissue regeneration, blood vessel growth, nerve regeneration, and antioxidant defense while suppressing genes associated with inflammation, cancer pathways, and fibrosis

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Challenges such as intestinal metabolism, efflux mechanisms in the gastrointestinal tract, and the hepatic first-pass effect hinder the oral bioavailability of drugs (46)(47)

Summary: No natural supplement has been shown to replicate the clinical benefits of prescribed GLP-1 or GIP receptor agonists for diabetes management or weight loss

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