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Both selective AMYR agonists, and dual CTR and AMYR agonists such as sCT 5,6,7 , have demonstrated efficacy in controlling appetite and body weight, however this is not seen with a CTR-selective agonist 9

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25 This combination might increase impacts on substrate utilization, energy intake, and energy expenditure

Tirzepatide is administered once weekly via subcutaneous injection, with doses ranging from 2.5 mg to 15 mg depending on therapeutic goals and tolerability