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(2025), in a network meta-analysis of 22 RCTs (2,258 participants) published in Metabolism, reported a mean difference of 0.86 kg lean mass for GLP-1 receptor agonists versus placebo, corresponding to roughly 25% of total weight loss

We observed that for each dose of semaglutide, even with the small number of patients continuing therapy beyond 7 months, there was a trend to achieve greater weight loss with continued semaglutide (see supplementary)

And it, you know, depending on which muscle we look at, they can lose between 5 and 20% of the muscle mass in one week

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Stress management deserves particular attention, as chronic stress alters cortisol patterns and inflammatory regulation in ways that can directly exacerbate autoimmune activity

If B12 is given without adequate folate, the methylation cycle can become inefficient