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Glutathione is also a constituent in the regulation of protein and gene expression, exchange reactions including thiol to disulfide ratios involve glutathione.[4] Glutathione can exist intracellularly in either an oxidized (glutathione disulfide) or reduced (glutathione) molecular state

Other types of severe reactions can occur in the stomach, small intestine and large intestine

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Glutathione protects cells from curcumin metabolites and limits their effects [17]

A recent small study of healthy older adults given glyNAC, a supplement that increases glutathione levels, showed lower oxidative stress and inflammation after 24 weeks of treatment