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John Myers in the 1960s

Chichlowski M, De Lartigue G, German JB, Raybould HE, Mills DA (2012) Bifidobacteria isolated from infants and cultured on human milk oligosaccharides affect intestinal epithelial function

The CDC criteria require disabling fatigue lasting more than 6 months that cannot be explained by exclusionary medical or psychiatric diagnoses) 8,9,10 plus at least 4 of 8 ancillary symptoms: short term memory of concentration problems, sore throat, sore lymph nodes, myalgia, arthralgia, headache, sleep disturbance, and post-exertional malaise (exertional exhaustion)

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The FDA reviewed data to assess these risks and found limited human studies on a few peptide therapies

2020;15(1):e0227046