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3.1.3 Profound links between dysregulation of iron metabolism and I/R AKI Iron metabolic homeostasisgoverned by absorption, utilization, and recyclingis critical for suppressing ferroptosis: disruption of this balance elevates free iron, which accelerates ROS accumulation via the Fenton reaction and renders cells more susceptible to ferroptosis (45, 82)

doi:10.1111/j.1743-6109.2007.00610.x Preparation and storage Research-only handling information