It also enhances cellular permeability, causes DNA damage through the generation of bulky adducts like N2-acetaldehyde deoxyguanine, alters the activity of enzyme convertases, and disrupts cellular oxidative balance by binding to glutathione reductase, resulting in lipid peroxidation and the formation of hydroxyl radicals [184]
It should be noted that BDNF is not only of clinical relevance but also relevant in Human Biomonitoring Programs 10,24
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This finding suggests that the peptides tolerability is not dependent on metabolic dysfunction and may apply across a broader population spectrum
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