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Gastrointestinal diseases drive the fastest fluid loss The gut is the bodys biggest fluid pathway, so any disease that disrupts it drains water and electrolytes fast

doi: 10.4103/jcrt.JCRT_862_16 165 GonzalezACasadoJChuecaESalillasSVelazquez-CampoyAEspinosa AngaricaVet al

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Starting with lower doses and gradually increasing helps minimize these effects