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10.3233/JPD-181503 75 ZhengD.LiN.HouR.ZhangX.WuL.SundquistJ.et al (2023)
The most frequently reported side effects include: Nausea (affecting approximately 1040% of patients, depending on the specific medication) Vomiting Diarrhoea Constipation Abdominal discomfort or bloating Reduced appetite These effects typically occur because GLP-1 medications slow gastric emptying and affect gut motility
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Testing of the metabolites and analogs indicated that curcumin was the major naturally occurring activator of GPR55 and that both the methoxy group and the heptadienone moiety of curcumin were required for the maximal effects
A: Tirzepatide (Mounjaro, Zepbound) is a dual GLP-1/GIP receptor agonist
Studies show 1,500 milligrams, in divided doses throughout the day, can help relieve nausea
