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245 E3 ligases from the NEDD4 family, such as NEDD4-2, SMURF1, SMURF2, and WWP1, are key regulators of this pathway

Atkins, C

Li F, Lang F, Wang Y, Zhai C, Zhang C, Zhang L, et al

Work to date concentrates on canonical pathways, leaving the core ferroptotic circuits, molecular targets and regulatory networks that drive retinal microvascular endothelial-cell (RMEC) injury undefined