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Immunostaining of lung tissue from the same regions on which we performed gene expression analysis localized SMAD2, a down-stream signal transducer of TGF, to the alveolar and airway walls while members of the bone morphogenetic protein (BMP) pathway, including SMAD6 and SMAD1, were primarily seen in vascular endothelial cells (Additional file 9)

Proactively identifying and addressing barriers within the control of primary care is essential to improving patient outcomes, as is a collaborative approach to care by all members of the primary care team