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As a triple-receptor agonist targeting GIP, GLP-1, and glucagon receptors simultaneously, it follows a specific dose escalation schedule that changes every four weeks

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and participates in the action of serotonin, a neurotransmitter known to control mood and appetite

The study involved a single-dose, randomized, double-blind, crossover design with tesofensine, placebo, D-amphetamine (used as a positive control for dopaminergic/stimulant effects), bupropion, and atomoxetine (used as negative/unscheduled controls)