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However, acylcarnitine was shown to reduce the levels of specific claudin proteins and alter the barrier function of tight junctions in Caco-2 cell monolayers and is should be cautiously considered for people who already have intestinal barrier problems [237]

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Brownstein says that high sugar and sodium content can also upset some peoples stomachs, and that you should read the labels to help you avoid over-supplementing (or over-caffeinating)

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