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Chakrabarty, Bhattacharyya, Christopher, & Khanna, 2005

Approaches to improvements in efficacy primarily target additional gut hormones via dual- and tri-agonists, and if Mounjaro provides any indication, dual- and tri-agonists may not be likely to enhance tolerability

PMCID: PMC5384512

El-Kashef DH, Serrya MS

Unfortunately, synthetic folic acid can be highly problematic for individuals with the MTHFR gene variation, as they may have a difficult time processing this form of folate

Monitor for excessive gastrointestinal distress (nausea, vomiting, diarrhoea), significant mood changes or anxiety, unusual fatigue, sleep disturbances, and signs of dehydration