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Since hippocampal atrophy is a hallmark of major depression, compounds that protect and potentially restore hippocampal tissue address a fundamental aspect of the disease process

Lancet Gastroenterol Hepatol 2023;8:17991.ArticlePubMed 82

This review has delineated the physiological and pathological roles of O-GlcNAcylation, elucidated the molecular mechanisms underpinning these functions, and underscored its protective potential in CNS diseases

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