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In non-epithelial NENs, Paraganglioma/Pheochromocytoma also showed GLP- 1R expression (13%, Table 1)

[PubMed: 10647754] 24

rs12129861 in PDZK1 is considered a risk allele for gout (Butler et al., 2021)

11.6 Evidence-Based Position Based on current literature: GLP-1 receptor agonists do not inherently cause universal nutrient depletion Intake-related vulnerability is plausible and patient-dependent Long-term micronutrient data remain limited Risk increases with magnitude and duration of weight loss Structured dietary strategy is protective Weight loss pharmacotherapy should be paired with nutritional planning

5 The most well-known mechanism through which GLP-1RAs affect weight loss is through the endocrine pathway, but its role in the nervous system should not be overlooked

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